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In organisms such as the nematode (roundworm), Caenorhabditis elegans , and the fruit fly, Drosophila melanogaster , experiments have shown that elevated levels of kynurenine are directly correlated to reduced life span

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Adipose tissue is a significant source of pro-inflammatory cytokines such as IL-1, IL-6, TNF-, Intercellular Adhesion Molecule 1 (ICAM1), Monocyte Chemoattractant Protein-1 (MCP-1), and adipokines like LEP and adiponectin

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Rodriguez-Colman MJ, Dansen TB, Burgering BMT (2024) Foxo transcription factors as mediators of stress adaptation